![]() ![]() THE BIPOTENTIAL GONAD No sexual difference can be observed in the gonads until the 6 th week of embryonic life in humans and 11.5 days post-coitum (dpc) in mice. Since the presence of the fetal testis plays a determining role in the differentiation of the reproductive tract, the term sex determination has been coined to designate the differentiation of the gonad during early fetal development. Subsequently, internal and external genitalia will follow the male pathway in the presence of specific testicular hormones, or the female pathway in their absence. Genetic sex, as determined by the chromosome constitution, drives the primitive gonad to differentiate into a testis or an ovary. Here we review the sexually undifferentiated stage of embryonic development, and the anatomic, histologic, physiologic and molecular aspects of the fetal sexual differentiation of the gonads, the internal reproductive tract and the external genitalia. Subsequently, internal and external genitalia will follow the male pathway in the presence of androgens and anti-Mllerian hormone (AMH), or the female pathway in their absence. ![]() The presence or absence of primordial germ cells, of extragonadal origin, also has a sexually dimorphic relevance. Controlador Ethernet 1969 1083 Nodbox Install Disk AntivirusĬontrolador Ethernet 1969 1083 Nodbox Install Disk Antivirus.Controlador Ethernet 1969 1083 Nodbox Series Of Events. ![]()
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